What is involved in running a league? Is there out of pocket expense, etc? Depending on what's required, i might consider running one in my Town.
You have to find a safe place for it to be held. I don't think you could have it at your home. You have to have it at a game store or a school/library. Some of these places might charge a fee for you to use the space so either you would have to pay it or charge league members a small fee. You can get POP packs and league books, materials, etc. sent to you by POP once you have found a place.
local libraries and community centers are also great places to run a League. I personally frequent one that's in a community center. One of the biggest Leagues in the country is run out of a WalMart's McDonald's store. Be creative, you never know where you might be able to find a good location!