Yeah, as a skittles player for the last year, someone built this at my league.
Im winning on a 70-30 basis, but this matchup is NOT unwinnable.
Special conditions are your friends. Use the Plume and burn to make sure Ho-oh doesn't get to flip. The less chances of Turning, the better.
You are going to lose at least one oddish, try not to set up your first active. Set up a Bella on your bench for after the first Ho-oh knockout.
Weakness makes it so that a ho-oh with 4 energies can KO a bella. Do not run bubble coat. The person at my league tried it. Bubble coat just isn't worth it in this deck.
Don't underestimate Vileplume's attack. If you rush a plume and attach a multi to stop Skittles starter, you should win the match.
Otherwise, just avoid play mistakes. It's difficult, but not unwinnable.